Preg-CoV: Trials and Tribulations
During September 2023, VACCELERATE hosted a webinar exploring the Preg-CoV trial, run by our team at St George’s Vaccine Institute at St George’s, University of London. Professor Paul Heath (Director of St George’s Vaccine Institute) and Dr Eva Galiza (Senior Clinical Research Fellow at St George’s Vaccine Institute) presented at the webinar, introducing the Preg-CoV trial, explaining the details of the study protocol, describing the challenges of running a pregnancy vaccine trial during a pandemic, evaluating the preliminary results and conclusions and lastly discussing the benefits of an adaptive pregnancy vaccine platform for future vaccine evaluations.
The Preg-CoV platform trial aimed to identify the optimal time to administer COVID-19 vaccines in pregnancy to best protect pregnant women against COVID-19. The trial provides clinical trial data on the immune response to vaccination in women and their infants, when given at different dose intervals and at different times in pregnancy. The trial involved over 300 pregnant women who were vaccinated with available COVID-19 vaccines. They were closely monitored by health professionals throughout their pregnancy and following the birth, with the safety of the women and their babies being of utmost importance. The Preg-CoV participants were between 18 and 44 years old, had no major health conditions and were between 13 and 34 weeks pregnant on the day of vaccination. They received 2 doses of a COVID-19 vaccine in pregnancy – or one booster dose if they had already received primary vaccination.
To watch the full webinar, please see YouTube video featured below.
Presenters: Paul Heath, Eva Galiza
Moderator: Zoi-Dorothea Pana
Organiser: VACCELERATE (Coordinator: Prof. Oliver A. Cornely)
