Mycobacterium Tuberculosis (TB)

Tuberculosis (TB), caused by the bacteria Mycobacterium tuberculosis remains a globally prevalent and lethal infectious disease, causing 1.6 million deaths annually. This is despite anti-TB antibiotics and global health initiatives. TB treatment and control has many challenges, including difficulties with diagnostic tests, long treatment duration (6-18 months), relapse and antibiotic resistance.  

Despite a high cure rate, TB can cause permanent damage to the lungs, heart, brain, eyes, spine, gut and kidneys. Anyone can catch TB, and it does not appear that people can mount very effective immune responses to it. The BCG vaccine is not highly effective and so only gives a small amount of additional protection. The vaccine institute is continuing research into this disease to contribute to its eradication. Current studies are examining better tests for TB to improve detection and treatment of this disease.