Tatiana (Taty) is the Operations Manager responsible for the strategic planning and overall direction of the group.  She is a group leader with more than 10 years’ experience coordinating and managing a large international portfolio of research studies, including observational studies and phase I-IV adult, maternal, paediatric and neonatal clinical trials funded by national and international agencies and commercial companies. She is a microbiologist by training and joined the PIDRG in 2010 after finishing her PhD in Molecular Biology at Imperial College London.

• Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial – PubMed (nih.gov)
• Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds – PubMed (nih.gov)
• Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein – PubMed (nih.gov)
• Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway – PubMed (nih.gov)
• Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH – PubMed (nih.gov)

Dr Eva Galiza joined the St. George’s Vaccine Institute (SGVI) in 2006 and has taken part in a wide range of paediatric and adult research work including observational, interventional phase 1-4, CTIMP and non-CTIMPS, and both commercial and non-commercial studies. As the Senior Clinical Research Fellow, Dr Galiza leads and co-ordinates vaccine trials and other infectious diseases studies run by SGVI and the Paediatric Infectious Diseases Research Group (PIDRG), part of the Institute for Infection and Immunity at St. George’s, University of London. She is Principal Investigator for several infectious diseases studies including RSV and coronavirus (COVID-19) vaccine research trials. Currently, Dr Galiza is the lead fellow and coordinator for the Preg-CoV trial looking at COVID-19 vaccines in pregnancy.

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine.

Heath PT, Galiza EP, Baxter DN, Boffito M, Browne D, Burns F, Chadwick DR, Clark R, Cosgrove C, Galloway J, Goodman AL, Heer A, Higham A, Iyengar S, Jamal A, Jeanes C, Kalra PA, Kyriakidou C, McAuley DF, Meyrick A, Minassian AM, Minton J, Moore P, Munsoor I, Nicholls H, Osanlou O, Packham J, Pretswell CH, San Francisco Ramos A, Saralaya D, Sheridan RP, Smith R, Soiza RL, Swift PA, Thomson EC, Turner J, Viljoen ME, Albert G, Cho I, Dubovsky F, Glenn G, Rivers J, Robertson A, Smith K, Toback S; 2019nCoV-302 Study Group.

N Engl J Med. 2021 Jun 30:NEJMoa2107659. doi: 10.1056/NEJMoa2107659. Online ahead of print. PMID: 34192426

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial.

Emary KRW, Golubchik T, Aley PK, Ariani CV, Angus B, Bibi S, Blane B, Bonsall D, Cicconi P, Charlton S, Clutterbuck EA, Collins AM, Cox T, Darton TC, Dold C, Douglas AD, Duncan CJA, Ewer KJ, Flaxman AL, Faust SN, Ferreira DM, Feng S, Finn A, Folegatti PM, Fuskova M, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hallis B, Heath PT, Hay J, Hill HC, Jenkin D, Kerridge S, Lazarus R, Libri V, Lillie PJ, Ludden C, Marchevsky NG, Minassian AM, McGregor AC, Mujadidi YF, Phillips DJ, Plested E, Pollock KM, Robinson H, Smith A, Song R, Snape MD, Sutherland RK, Thomson EC, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Williams CJ, Hill AVS, Lambe T, Gilbert SC, Voysey M, Ramasamy MN, Pollard AJ; COVID-19 Genomics UK consortium; AMPHEUS Project; Oxford COVID-19 Vaccine Trial Group.

Lancet. 2021 Apr 10;397(10282):1351-1362. doi: 10.1016/S0140-6736(21)00628-0. Epub 2021 Mar 30. PMID: 33798499

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Clutterbuck EA, Collins AM, Cutland CL, Darton TC, Dheda K, Dold C, Duncan CJA, Emary KRW, Ewer KJ, Flaxman A, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hill C, Hill HC, Hirsch I, Izu A, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Libri V, Lillie PJ, Marchevsky NG, Marshall RP, Mendes AVA, Milan EP, Minassian AM, McGregor A, Mujadidi YF, Nana A, Padayachee SD, Phillips DJ, Pittella A, Plested E, Pollock KM, Ramasamy MN, Ritchie AJ, Robinson H, Schwarzbold AV, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, White T, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2021 Mar 6;397(10277):881-891. doi: 10.1016/S0140-6736(21)00432-3. Epub 2021 Feb 19. PMID: 33617777

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. PMID: 33306989

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.

Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, Bellamy D, Bibi S, Bittaye M, Clutterbuck EA, Dold C, Faust SN, Finn A, Flaxman AL, Hallis B, Heath P, Jenkin D, Lazarus R, Makinson R, Minassian AM, Pollock KM, Ramasamy M, Robinson H, Snape M, Tarrant R, Voysey M, Green C, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2020 Aug 15;396(10249):467-478. doi: 10.1016/S0140-6736(20)31604-4. Epub 2020 Jul 20. PMID: 32702298

Shari is a paediatric trainee in London with a special interest in maternal and child health within the field of infectious diseases. Her roles within the PIDRG and SGVI as a clinical research fellow involve working on projects relating to vaccinology in maternal and child health, as well as a special focus on maternal and congenital cytomegalovirus infection. Shari is also a PhD student at St George’s University of London, where her  thesis focuses on the area of maternal and congenital cytomegalovirus infection, which involves one of the PIDRG projects she is working on as the Principal Investigator.

Sapuan S, Kortsalioudaki C, Anthony M, Chang J, Embleton ND, Geethanath RM et al. Neonatal
Listeriosis in the UK 2004-2014. Journal of Infection. 2016 Nov 17. Available
from: 10.1016/j.jinf.2016.11.007

Alberto is an Infectious Diseases and Microbiology Specialist Registrar with an interest in Global Health and Emerging Infectious Diseases. Alberto joined SGVI as part of a research placement in September 2020 and is currently working as an Adult clinical research fellow in several COVID-19 vaccine trials. He is the lead fellow for the COM-COV and COM-COV2 studies looking at heterologous COVID-19 vaccine schedules.

Alberto is also involved in studying vaccine responses in immunocompromised patients. He is investigating immune responses to meningococcal vaccinations (MenACWY and MenB) in HIV+ patients (ProPositive and Propositive follow-up trials), as well as the immunogenicity of COVID-19 vaccination in Tuberous Sclerosis Complex patients taking mTor inhibitor therapy.

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine. N Engl J Med. 2021 Jun 30. doi: https://doi.org/10.1056/NEJMoa2107659.

Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data. The Lancet Volume 397, Isuue 10289, P2043-2046, May 29, 2021. Part of Com-COV Study group. https://doi.org/10.1016/S0140-6736(21)01115-6

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. The Lancet Volume 397, Issue 10282, 10–16 April 2021, Pages 1351-1362. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(21)00628-0

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 6-12 March; 397(10277): 881–891. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(21)00432-3

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 2020 Dec 8;S0140-6736(20)32661-1. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(20)32661-1

Natalina is currently a Clinical Research Fellow at St George’s Paediatric Infectious Diseases Research Group, working on COVID-19 and MenACWY vaccine studies. She has over a decades experience in child health in global settings. She has applied 6 years of experience as a foundation doctor and paediatric trainee to global public health work including, participation in mobile clinics to ensure access to healthcare for remote populations in Belize, and development of health promotion projects in Ecuador and Mexico. Natalina has a MSc in Public Health from the London School of Hygiene and Tropical Medicine and has carried out research projects on predicting IVIG resistance in Kawasaki Disease and prevention of childhood obesity in preschool children.

Heath PT, Galiza EP, Baxter DN, Boffito M, Browne D, Burns F, Chadwick DR, Clark R, Cosgrove C, Galloway J, Goodman AL, Heer A, Higham A, Iyengar S, Jamal A, Jeanes C, Kalra PA, Kyriakidou C, McAuley DF, Meyrick A, Minassian AM, Minton J, Moore P, Munsoor I, Nicholls H, Osanlou O, Packham J, Pretswell CH, San Francisco Ramos A, Saralaya D, Sheridan RP, Smith R, Soiza RL, Swift PA, Thomson EC, Turner J, Viljoen ME, Albert G, Cho I, Dubovsky F, Glenn G, Rivers J, Robertson A, Smith K, Toback S; 2019nCoV-302 Study Group. Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine. N Engl J Med. 2021 Jun 30

Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. Erratum in: Lancet. 2021 Jan 9;397(10269):98.
Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Clutterbuck EA, Collins AM, Cutland CL, Darton TC, Dheda K, Dold C, Duncan CJA, Emary KRW, Ewer KJ, Flaxman A, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hill C, Hill HC, Hirsch I, Izu A, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Libri V, Lillie PJ, Marchevsky NG, Marshall RP, Mendes AVA, Milan EP, Minassian AM, McGregor A, Mujadidi YF, Nana A, Padayachee SD, Phillips DJ, Pittella A, Plested E, Pollock KM, Ramasamy MN, Ritchie AJ, Robinson H, Schwarzbold AV, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, White T, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 Mar 6;397(10277):881-891.

Davies S, Sutton N, Blackstock S, Gormley S, Hoggart CJ, Levin M, Herberg JA. Predicting IVIG resistance in UK Kawasaki disease. Arch Dis Child. 2015 Apr;100(4):366-8.

Simon Drysdale is a consultant and honorary senior lecturer in paediatric infectious diseases and immunology at St George’s University Hospitals NHS Foundation Trust. He is the paediatric antimicrobial stewardship lead at St George’s and principal investigator on several clinical trials investigating diagnostics, novel treatments and prophylactics for RSV and SARS-CoV-2. His research interests are host susceptibility to RSV and other respiratory viral infections and antimicrobial resistance and stewardship.

1. Drysdale SB, Kelly DF, Morgan M, Peto T, Crook D, Matthews PC, Walker TM. Case Report: Disseminated, rifampicin resistant Mycobacterium bovis (BCG) infection in an immunocompromised child. Wellcome Open Research 2020; 5: 242.
2. Lin GL, Golubchik T, Drysdale S, O’Connor D, Jefferies K, Brown A, de Cesare M, Bonsall D, Ansari MA, Aerssens J, Bont L, Openshaw P, Martinón-Torres F, Bowden R, Pollard AJ. Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants. J Infect Dis. 2020 Jul 23:jiaa448. doi: 10.1093/infdis/jiaa448. Online ahead of print.
3. Jefferies K, Drysdale SB, Robinson H, Clutterbuck EA, Blackwell L, McGinley J, Lin GL, Galal U, Nair H, Aerssens J, Öner D, Langedijk A, Bont L, Wildenbeest JG, Martinon-Torres F, Rodríguez-Tenreiro Sánchez C, Nadel S, Openshaw P, Thwaites R, Widjojoatmodjo M, Zhang L, Nguyen TL, Giaquinto C, Giordano G, Baraldi E, Pollard AJ; Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators. Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae: Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU). J Infect Dis. 2020 Aug 14:jiaa239. doi: 10.1093/infdis/jiaa239. Online ahead of print.
4. Öner D, Drysdale SB, McPherson C, Lin GL, Janet S, Broad J, Pollard AJ, Aerssens J; RESCEU Investigators. Biomarkers for Disease Severity in Children Infected With Respiratory Syncytial Virus: A Systematic Literature Review. J Infect Dis. 2020 Aug 14:jiaa208. doi: 10.1093/infdis/jiaa208. Online ahead of print.
5. Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Airway response to respiratory syncytial virus has incidental antibacterial effects. Nat Commun. 2019;10(1):2218. doi: 10.1038/s41467-019-10222-z.

Zsofia has been working in clinical paediatrics since 2014 and finished Paediatric training in November 2020. Zsofia started working for the paediatric infectious disease research group in September 2020. Her role as a clinical research fellow (currently mainly involved in the COVID-19 vaccine trials) includes recruitment and consenting of participants, reviewing medical history, vaccinating, conducting symptomatic reviews and covering on-call duties. Zsofia also works on the cChips CMV study and looking forward to be involved in other paediatric trials as well.

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

A Folyovich, I Vastagh, A Kéri, A Majoros, KL Kovács, A Ajtay, Zs Laki, B Gunda, K Erdei, L Lenti, Zs Dános, D Bereczki  Living standard is related to microregional differences in stroke characteristics in Central Europe: the Budapest Districts 8-12 Project  Int J Public Health  DOI 10.1007/s00038-015-0674-y  2015

D. Bereczki, A. Ajtay, A. Majoros, Z. Dános, L. Lenti, K. Erdei, L.K. Kovács, B. Gunda, Z. Laki, A. Kéri, I, Vastagh, A. Folyovich  Gender difference in the living standard on 3-year stroke fatality: the Budapest District 8-12 project.

David is an Infectious Diseases trainee currently undertaking a research placement. Having published work on Vitamin D in latent TB patients and its association with progression to active disease David is now working on a pilot study to increase the sensitivity of TB culture and detect persistent sub-populations of Mycobacteria within patient samples. This pilot data will inform the design of future large clinical trials of these techniques. David has also been working on a number of COVID-19 vaccine trials including leading on the COV001/002 and Valneva trials, and have published editorials on important topics in COVID-19. David previously completed laboratory research on respiratory virus’s effects on the ubiquitin intracellular pathways as part of an intercalated degree at Oxford University.

Smith, D., & Gill, D. (2021). Antivirals against SARS-CoV-2 by autumn?. BMJ, 373, n1215. doi:10.1136/bmj.n1215

Burgess, S., Smith, D., Kenyon, J. C., & Gill, D. (2020). Lightening the viral load to lessen covid-19 severity.. BMJ, 371, m4763. doi:10.1136/bmj.m4763

Patterson, B., Smith, D., Telford, A., Tana, A., Johnstone, D., Davidson, R., & Martineau, A. R. (2020). Vitamin D deficiency predicts latent TB reactivation independent of preventive therapy: a longitudinal study.. Int J Tuberc Lung Dis, 24(9), 916-921. doi:10.5588/ijtld.19.0605