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Project Team

Adult Clinical Research Fellow

Alberto San Francisco Ramos

Paediatric Clinical Research Fellow

Anna Calvert

Paediatric Research Nurse

Aoife Mescall

Paediatric Research Nurse

Cecilia Hultin

Adult Clinical Research Fellow

David Smith

Co-Director

Dr Catherine Cosgrove

Paediatric Research Nurse

Elena Stefanova

Senior Clinical Research Fellow

Eva Galiza

Paediatric Research Nurse

Fran Mabesa

Vaccine Programme Manager

Hana Tabusa

Project Officer

Hannah Sharp

Paediatric Clinical Research Fellow

Hazel Fofie

Senior Research Nurse

Jennifer Pearce

Project Officer

Jonathan Lewis-Bridgeman

Paediatric Research Nurse

Josyanne Paquete Pereira

Professor

Julian Ma

Administrator

Kalynka Bellman

Professor

Kirsty LeDoare

Infectious Diseases Research Nurse

Luis de Luna

Professor

Mike Sharland

Neonatal Research nurse

Naomi Hayward

Paediatric Clinical Research Fellow

Natalina Sutton

Paediatric Research Nurse

Nicole Branch

Director

Paul Heath

Project Manager

Polly Fox

Adult Clinical Research Fellow

Sabina Ikram

Project Manager

Sabrina Kapur

Professor in Paediatric Infectious Diseases

Shamez Ladhani

Paediatric Clinical Research Fellow

Shari Sapuan

Paediatric Research Nurse

Shehnaz Athaide

Project Officer

Shivani Patel

Consultant in Paediatric Infectious Diseases

Simon Drysdale

Project Manager

Suzannah Wright

Operations Manager

Tatiana Munera Huertas

Project Manager

Uzma Khan

Research Midwife

Vanessa Greening

Paediatric Clinical Research Fellow

Zsofia Danos

Adult Clinical Research Fellow

Alberto San Francisco Ramos

Alberto is an Infectious Diseases and Microbiology Specialist Registrar with an interest in Global Health and Emerging Infectious Diseases. Alberto joined SGVI as part of a research placement in September 2020 and is currently working as an Adult clinical research fellow in several COVID-19 vaccine trials. He is the lead fellow for the COM-COV and COM-COV2 studies looking at heterologous COVID-19 vaccine schedules.

Alberto is also involved in studying vaccine responses in immunocompromised patients. He is investigating immune responses to meningococcal vaccinations (MenACWY and MenB) in HIV+ patients (ProPositive and Propositive follow-up trials), as well as the immunogenicity of COVID-19 vaccination in Tuberous Sclerosis Complex patients taking mTor inhibitor therapy.

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine. N Engl J Med. 2021 Jun 30. doi: https://doi.org/10.1056/NEJMoa2107659.

Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data. The Lancet Volume 397, Isuue 10289, P2043-2046, May 29, 2021. Part of Com-COV Study group. https://doi.org/10.1016/S0140-6736(21)01115-6

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. The Lancet Volume 397, Issue 10282, 10–16 April 2021, Pages 1351-1362. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(21)00628-0

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 6-12 March; 397(10277): 881–891. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(21)00432-3

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 2020 Dec 8;S0140-6736(20)32661-1. Part of Oxford Vaccine Group. https://doi.org/10.1016/S0140-6736(20)32661-1

Paediatric Clinical Research Fellow

Anna Calvert

Anna is a clinical research fellow who has been working with PIDRG since 2015. Her main interests are in maternal and infant vaccination, particularly in infants born preterm, and she is currently working on her PhD investigating invasive meningococcal disease in preterm infants.

Wilcox CR, Calvert A, Metz J, Kilich E, MacLeod R, Beadon K, Heath PT, Khalil A, Finn A, Snape MD, et al. Attitudes of Pregnant Women and Healthcare Professionals Toward Clinical Trials and Routine Implementation of Antenatal Vaccination Against Respiratory Syncytial Virus: A Multicenter Questionnaire Study. Pediatr Infect Dis J 2019; 38: 944-951

Vandrevala T, Barber V, Calvert A, Star C, Khalil A, Griffiths P, Heath PT, Jones CE. Understanding pregnant women’s readiness to engage in risk-reducing measures to prevent infections during pregnancy. J Health Psychol. November 2019. doi:10.1177/1359105319884609

Tregoning JS, Weiner J, Cizmeci D, Hake D, Maertzdorf J, Kaufman SHE, Leroux-Roels G, Maes C, Aerssens A, Calvert A, et al. Pregnancy has a minimal impact on the acute transcriptional signature to vaccination. NPJ Vaccines 2020; 5:29
Barber V, Calvert A, Vandrevala T, Star C, Khalil A, Griffiths P, Heath PT, Jones CE. Prevention of Acquisition of Cytomegalovirus Infection in Pregnancy Through Hygiene-based Behavioural Interventions: A Systematic Review and Gap Analysis. Pediatr Infect Dis J 2020; 39:949-954

Vandrevala T, Barber V, Mbire-Chigumba E, Calvert A, Star C, Khalil A, Griffiths P, et al. Parenting a child with congenital cytomegalovirus infection: a qualitative study. BMJ Paediatr Open 2020; 4: e000844

Paediatric Research Nurse

Aoife Mescall

Aoife has a Bachelor of Science Honours degree in Nursing and Health Sciences. She has worked in St Georges since 2013 and worked for 1.5 years on the Neuro Intensive Care Unit before moving to the Neonatal Unit where she completed a post graduate course in neonatal nursing and worked as a Neonatal Intensive Care nurse for 6 years.

Aoife has worked with PIDRG since October 2020, primarily working on COVID-19 vaccine trials on the unblinded side. Aoife is also involved in recruitment for Urgent Public Health Studies such as a serological survey in children and young adults.

Paediatric Research Nurse

Cecilia Hultin

Adult Clinical Research Fellow

David Smith

David is an Infectious Diseases trainee currently undertaking a research placement. Having published work on Vitamin D in latent TB patients and its association with progression to active disease David is now working on a pilot study to increase the sensitivity of TB culture and detect persistent sub-populations of Mycobacteria within patient samples. This pilot data will inform the design of future large clinical trials of these techniques. David has also been working on a number of COVID-19 vaccine trials including leading on the COV001/002 and Valneva trials, and have published editorials on important topics in COVID-19. David previously completed laboratory research on respiratory virus’s effects on the ubiquitin intracellular pathways as part of an intercalated degree at Oxford University.

Smith, D., & Gill, D. (2021). Antivirals against SARS-CoV-2 by autumn?. BMJ, 373, n1215. doi:10.1136/bmj.n1215

Burgess, S., Smith, D., Kenyon, J. C., & Gill, D. (2020). Lightening the viral load to lessen covid-19 severity.. BMJ, 371, m4763. doi:10.1136/bmj.m4763

Patterson, B., Smith, D., Telford, A., Tana, A., Johnstone, D., Davidson, R., & Martineau, A. R. (2020). Vitamin D deficiency predicts latent TB reactivation independent of preventive therapy: a longitudinal study.. Int J Tuberc Lung Dis, 24(9), 916-921. doi:10.5588/ijtld.19.0605

Co-Director

Dr Catherine Cosgrove

Paediatric Research Nurse

Elena Stefanova

I have graduated as a paediatric nurse in 1998, have been practising in the UK since 2011. Joined the research team at St George’s Hospital, London in March 2017.

Since then and currently have been involved in various studies-neurology, neurosurgery, gastroenterology, infectious diseases, with main focus on antimicrobial resistance and vaccine studies.

Senior Clinical Research Fellow

Eva Galiza

Dr Eva Galiza joined the St. George’s Vaccine Institute (SGVI) in 2006 and has taken part in a wide range of paediatric and adult research work including observational, interventional phase 1-4, CTIMP and non-CTIMPS, and both commercial and non-commercial studies. As the Senior Clinical Research Fellow, Dr Galiza leads and co-ordinates vaccine trials and other infectious diseases studies run by SGVI and the Paediatric Infectious Diseases Research Group (PIDRG), part of the Institute for Infection and Immunity at St. George’s, University of London. She is Principal Investigator for several infectious diseases studies including RSV and coronavirus (COVID-19) vaccine research trials. Currently, Dr Galiza is the lead fellow and coordinator for the Preg-CoV trial looking at COVID-19 vaccines in pregnancy.

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine.

Heath PT, Galiza EP, Baxter DN, Boffito M, Browne D, Burns F, Chadwick DR, Clark R, Cosgrove C, Galloway J, Goodman AL, Heer A, Higham A, Iyengar S, Jamal A, Jeanes C, Kalra PA, Kyriakidou C, McAuley DF, Meyrick A, Minassian AM, Minton J, Moore P, Munsoor I, Nicholls H, Osanlou O, Packham J, Pretswell CH, San Francisco Ramos A, Saralaya D, Sheridan RP, Smith R, Soiza RL, Swift PA, Thomson EC, Turner J, Viljoen ME, Albert G, Cho I, Dubovsky F, Glenn G, Rivers J, Robertson A, Smith K, Toback S; 2019nCoV-302 Study Group.

N Engl J Med. 2021 Jun 30:NEJMoa2107659. doi: 10.1056/NEJMoa2107659. Online ahead of print. PMID: 34192426

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial.

Emary KRW, Golubchik T, Aley PK, Ariani CV, Angus B, Bibi S, Blane B, Bonsall D, Cicconi P, Charlton S, Clutterbuck EA, Collins AM, Cox T, Darton TC, Dold C, Douglas AD, Duncan CJA, Ewer KJ, Flaxman AL, Faust SN, Ferreira DM, Feng S, Finn A, Folegatti PM, Fuskova M, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hallis B, Heath PT, Hay J, Hill HC, Jenkin D, Kerridge S, Lazarus R, Libri V, Lillie PJ, Ludden C, Marchevsky NG, Minassian AM, McGregor AC, Mujadidi YF, Phillips DJ, Plested E, Pollock KM, Robinson H, Smith A, Song R, Snape MD, Sutherland RK, Thomson EC, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Williams CJ, Hill AVS, Lambe T, Gilbert SC, Voysey M, Ramasamy MN, Pollard AJ; COVID-19 Genomics UK consortium; AMPHEUS Project; Oxford COVID-19 Vaccine Trial Group.

Lancet. 2021 Apr 10;397(10282):1351-1362. doi: 10.1016/S0140-6736(21)00628-0. Epub 2021 Mar 30. PMID: 33798499

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials.

Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Clutterbuck EA, Collins AM, Cutland CL, Darton TC, Dheda K, Dold C, Duncan CJA, Emary KRW, Ewer KJ, Flaxman A, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hill C, Hill HC, Hirsch I, Izu A, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Libri V, Lillie PJ, Marchevsky NG, Marshall RP, Mendes AVA, Milan EP, Minassian AM, McGregor A, Mujadidi YF, Nana A, Padayachee SD, Phillips DJ, Pittella A, Plested E, Pollock KM, Ramasamy MN, Ritchie AJ, Robinson H, Schwarzbold AV, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, White T, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2021 Mar 6;397(10277):881-891. doi: 10.1016/S0140-6736(21)00432-3. Epub 2021 Feb 19. PMID: 33617777

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. PMID: 33306989

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial.

Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, Bellamy D, Bibi S, Bittaye M, Clutterbuck EA, Dold C, Faust SN, Finn A, Flaxman AL, Hallis B, Heath P, Jenkin D, Lazarus R, Makinson R, Minassian AM, Pollock KM, Ramasamy M, Robinson H, Snape M, Tarrant R, Voysey M, Green C, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group.

Lancet. 2020 Aug 15;396(10249):467-478. doi: 10.1016/S0140-6736(20)31604-4. Epub 2020 Jul 20. PMID: 32702298

Paediatric Research Nurse

Fran Mabesa

National Health Training College; Diploma in General Nursing Diploma in Midwifery.

Middlesex University; BSc in Occupational Safety, Health and Environment.

Vaccine Programme Manager

Hana Tabusa

Hana has worked in the field of clinical trials since 2013. She has worked on studies ranging from commercially sponsored studies to investigator-led studies funded by the NIHR, EU and charities. She has experience of coordinating research studies from the application process, through to set up, recruitment and analysis, close out and archiving. Hana spent 4 years working at the Bristol Trials Centre managing studies in colorectal disease, cardiac surgery and ophthalmology. She returned to the Paediatric Infectious Diseases Research Group in December 2020.

Project Officer

Hannah Sharp

Hannah has been working in the PIDRG since November 2020, primarily supporting the administrative challenges of the COVID-19 vaccine trials (such as Novavax and COV002) and paediatric trials.

In her role as a Project Officer Hannah manages the Com-COV and Com-COV2 studies, investigating the immunogenicity and reactogenicity of mixed vaccine schedules.

Initial results from this study were recently published in the Lancet

Hannah also currently coordinates two maternal studies, the Pfizer COVID Vaccine Maternal Study and the Pfizer GBS6 Study, as well as KD-CAAP, investigating treatments for Kawasaki disease.

Paediatric Clinical Research Fellow

Hazel Fofie

Senior Research Nurse

Jennifer Pearce

Jenny joined the team in January 2018 and has since become the senior research nurse. Currently heavily involved in Covid-19 vaccine trials and is involved in set up, recruitment, and follow up of participants. Her role also includes looking after the nursing team and helping to mentor junior staff starting their journey into research, this includes teaching infant/paediatric venepuncture and vaccination.

Email:jpearce@sgul.ac.uk

Ext:Ext 2316/3887/2780

Project Officer

Jonathan Lewis-Bridgeman

Jonathan is currently working as Project Officer within the P.I.D.R.G team located at St. George’s University Hospital. He oversees the coordination of clinical trial studies through setup, recruitment, data management and collection, finance and budgets; through to close-out.

Paediatric Research Nurse

Josyanne Paquete Pereira

Josyanne is a Clinical Research Nurse and recently joined the Paediatric Infectious Disease Research Group. Currently, Josyanne is working in Covid-19 vaccine trials within the Vaccine Institute and participates in the recruitment and safety follow up of adult participants. Josyanne has previously worked in Clinical Trials in Multiple Myeloma and in the transformational project 100,000 Genomes enrolling children with Rare diseases and their families.

Josyanne’s role as a Research Nurse involves recruitment, screening and enrolment of patients/participants and is involved in blood sampling, blood processing, administration of investigational medicinal products, monitoring of vital signs and data management.

Her background is operating theatres, where she worked as a scrub and anaesthetic nurse in adult and paediatric settings in several specialities.

Professor

Julian Ma

Julian Ma joined St. George’s in October 2003, leading a research team that specialises in immunology and the production of recombinant pharmaceuticals using plant biotechnology (molecular pharming). His research is particularly focused on using biotechnology tools to produce novel pharmaceutical proteins to improve global access to modern medicines.

Professor Ma graduated in Dentistry at Guy’s Hospital in 1983, where he also gained his PhD in Immunology under Prof Thomas Lehner, studying anti-microbial immunotherapy using monoclonal antibodies.

Professor Ma was the scientific co-ordinator of Pharma-Planta, from 2004-2011, a €12M European Union Framework Programme 6 project to develop pharmaceuticals from plant-derived proteins. He was subsequently awarded an ERC Advanced Grant to develop further plant biotechnology derived medicines to clinical trials. He is currently the Principal Investigator for Pharma-Factory, an €8.3M EU Horizon 2020 project to advance the commercial pipeline of products from molecular pharming.

He was the vice chair for the European COST Action on Molecular Farming from 2009-2013 that co-ordinated molecular farming research and policy activities in 28 European countries. He subsequently founded the International Society for Plant Molecular Farming and was the founding President 2013-2016.

Administrator

Kalynka Bellman

Kalynka has worked in Higher Education institutions in the UK for the past several years and has experience in programme management, events management, and human resources.

She is the team administrator for the PIDRG and has been working closely with the COVID19 clinical trials.

Professor

Kirsty LeDoare

Professor Le Doare joined the SGUL from Imperial College London in September 2018 as part of the Paediatric Infectious Diseases Research Group. She trained as a clinician-scientist in Paediatric Infectious Diseases in the UK, the Gambia and South Africa. Kirsty holds a Chair in Vaccinology and Immunology and is a Principal Scientist at MRC/UVRI@LSHTM in Uganda where she is developing a maternal vaccine platform and surveillance of pregnancy outcomes in a large urban cohort. She was awarded a UKRI Future Leaders Fellowship in 2019. In the UK and in Uganda her main research interests are age-related immune responses to infectious diseases in pregnant women and their babies. She is interested in improving our knowledge of how maternal antibody in blood and breast milk is passed to babies and how this protects them from colonisation and disease and how we might improve this with vaccination. Her group leads several clinical trials of investigative vaccines in Uganda. She is jointly appointed to Public Health England as a principal scientist with the Pathogen Immunity Group, Porton Down.

Tackling Group B Streptococcus (sgul.ac.uk)

www.gbsatstgeorges.co.uk

Infectious Diseases Research Nurse

Luis de Luna

Luis joined the Vaccine Institute in 2021 and is one of the research nurses supporting the COVID-19 trials and other studies carried out at St George’s.

Professor

Mike Sharland

Professor Mike Sharland is a leading expert in antimicrobial prescribing, resistance and healthcare associated infection in children. He is the lead clinical advisor for the neonatal and paediatric programme of the Global Antibiotic Research and Development Partnership (GARDP) and Vice-Chair and AMR lead of the Penta Foundation, a global Paediatric Infectious Diseases research network.

He previously Chaired the Department of Health’s Expert Advisory Committee of Antimicrobial Prescribing, Resistance and Healthcare Associated Infection (APRHAI). He has been an advisor for the WHO for many years. He is member of the Expert Committee on the Selection and Use of Essential Medicines and Chair of the Antibiotic Working Group of the EML/EMLc, assisting with the development of the Access/Watch/Reserve (AWaRE) grouping of antibiotics and WHO global targets on use.
Prof Sharland’s principal research interest is optimising the use of antimicrobials in children. At St George’s University London he leads a major program of research including global cohort studies and clinical trials to improve the evidence base for antimicrobial prescribing.

Tackling the Challenge of Antimicrobial Resistance in Children and Babies (sgul.ac.uk)

Neonatal Research nurse

Naomi Hayward

Paediatric Clinical Research Fellow

Natalina Sutton

Natalina is currently a Clinical Research Fellow at St George’s Paediatric Infectious Diseases Research Group, working on COVID-19 and MenACWY vaccine studies. She has over a decades experience in child health in global settings. She has applied 6 years of experience as a foundation doctor and paediatric trainee to global public health work including, participation in mobile clinics to ensure access to healthcare for remote populations in Belize, and development of health promotion projects in Ecuador and Mexico. Natalina has a MSc in Public Health from the London School of Hygiene and Tropical Medicine and has carried out research projects on predicting IVIG resistance in Kawasaki Disease and prevention of childhood obesity in preschool children.

Heath PT, Galiza EP, Baxter DN, Boffito M, Browne D, Burns F, Chadwick DR, Clark R, Cosgrove C, Galloway J, Goodman AL, Heer A, Higham A, Iyengar S, Jamal A, Jeanes C, Kalra PA, Kyriakidou C, McAuley DF, Meyrick A, Minassian AM, Minton J, Moore P, Munsoor I, Nicholls H, Osanlou O, Packham J, Pretswell CH, San Francisco Ramos A, Saralaya D, Sheridan RP, Smith R, Soiza RL, Swift PA, Thomson EC, Turner J, Viljoen ME, Albert G, Cho I, Dubovsky F, Glenn G, Rivers J, Robertson A, Smith K, Toback S; 2019nCoV-302 Study Group. Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine. N Engl J Med. 2021 Jun 30

Voysey M, Clemens SAC, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8. Erratum in: Lancet. 2021 Jan 9;397(10269):98.
Voysey M, Costa Clemens SA, Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie VL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Clutterbuck EA, Collins AM, Cutland CL, Darton TC, Dheda K, Dold C, Duncan CJA, Emary KRW, Ewer KJ, Flaxman A, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Galiza E, Goodman AL, Green CM, Green CA, Greenland M, Hill C, Hill HC, Hirsch I, Izu A, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Libri V, Lillie PJ, Marchevsky NG, Marshall RP, Mendes AVA, Milan EP, Minassian AM, McGregor A, Mujadidi YF, Nana A, Padayachee SD, Phillips DJ, Pittella A, Plested E, Pollock KM, Ramasamy MN, Ritchie AJ, Robinson H, Schwarzbold AV, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, White T, Williams CJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ; Oxford COVID Vaccine Trial Group. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet. 2021 Mar 6;397(10277):881-891.

Davies S, Sutton N, Blackstock S, Gormley S, Hoggart CJ, Levin M, Herberg JA. Predicting IVIG resistance in UK Kawasaki disease. Arch Dis Child. 2015 Apr;100(4):366-8.

Paediatric Research Nurse

Nicole Branch

I have worked with the PIDRG since January 2020 and moved across full-time in December 2020. I have previously worked in paediatric surgery and paediatric A&E at Birmingham Children’s Hospital and St George’s before transferring across into research. I am currently working on COVID-19 vaccine trials and DIAMONDS Search, a paediatric observational study.

Before re-training to become a paediatric nurse, I graduated in French and Spanish and was working as an English language teacher in France and Spain.

Director

Paul Heath

Email:pheath@sgul.ac.uk

Secretary Phone:020 8725 3262

Project Manager

Polly Fox

I joined the PIDRG Team in September 2019 as a Project Officer working on a range of studies in RSV, fungal infections, AMR and vaccines. I’m now one of the Project Managers helping to deliver the COVID-19 Vaccine Trials we are running at St George’s as well as other Urgent Public Health studies such as a serological survey in children and young adults. I have also recently started an MSc Clinical Trials with LSHTM part-time to further my career development in trial coordination.

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Adult Clinical Research Fellow

Sabina Ikram

Sabina is a GP with an interest in infectious diseases, global health and medical education. At St George’s University of London, she works as clinical research fellow in the Vaccine Institute and PIDRG. Her current work primarily focuses on the COVID-19 vaccine trials.

Seale J, Ragbourne SC, Bajarano NP, Raj R, Whittingham L, Ikram S, Butchers C. Training final year medical students in telephone communication and prioritization skills: An evaluation in the simulated environment. Medical Teacher. 2019 Available from: https://doi.org/10.1080/0142159X.2019.1610559

Seale J, Ikram S, Whittingham L, Butchers C. Combining medical, physiotherapy and nursing undergraduates in high-fidelity simulation: determining students’ perceptions. BMJ Simul Technol Enhanc Learn. 2018. Available from: http://dx.doi.org/10.1136/bmjstel-2017-000286

Project Manager

Sabrina Kapur

Professor in Paediatric Infectious Diseases

Shamez Ladhani

No Bio supplied

Paediatric Clinical Research Fellow

Shari Sapuan

Shari is a paediatric trainee in London with a special interest in maternal and child health within the field of infectious diseases. Her roles within the PIDRG and SGVI as a clinical research fellow involve working on projects relating to vaccinology in maternal and child health, as well as a special focus on maternal and congenital cytomegalovirus infection. Shari is also a PhD student at St George’s University of London, where her  thesis focuses on the area of maternal and congenital cytomegalovirus infection, which involves one of the PIDRG projects she is working on as the Principal Investigator.

Sapuan S, Kortsalioudaki C, Anthony M, Chang J, Embleton ND, Geethanath RM et al. Neonatal
Listeriosis in the UK 2004-2014. Journal of Infection. 2016 Nov 17. Available
from: 10.1016/j.jinf.2016.11.007

Paediatric Research Nurse

Shehnaz Athaide

I have been working in Vaccine Institute as an Adult Clinical Research Nurse since April 2019 till date. My work mainly focuses on collecting data for our current Adult research studies, recruiting participants, conducting clinical appointments, taking study related clinical samples, processing them and recording data on a secure system. I enjoy my work while being a part of vaccine research team at St. Georges University of London and NHS trust.

Project Officer

Shivani Patel

I am a graduate of the University of Brighton, where I completed my Bsc in Pharmaceutical Chemistry. I have 5 years of experience working within healthcare, and a year within clinical trials specifically. I joined the PIDRG team in November 2020 during the COVID-19 pandemic. Since joining I have been involved in the set up and day to day running of the Oxford COVID-19 vaccine trials for both adults and paediatrics. I am also currently involved with multiple RSV studies and also the paediatric observational study DIAMONDS.

Consultant in Paediatric Infectious Diseases

Simon Drysdale

Simon Drysdale is a consultant and honorary senior lecturer in paediatric infectious diseases and immunology at St George’s University Hospitals NHS Foundation Trust. He is the paediatric antimicrobial stewardship lead at St George’s and principal investigator on several clinical trials investigating diagnostics, novel treatments and prophylactics for RSV and SARS-CoV-2. His research interests are host susceptibility to RSV and other respiratory viral infections and antimicrobial resistance and stewardship.
  1. Drysdale SB, Kelly DF, Morgan M, Peto T, Crook D, Matthews PC, Walker TM. Case Report: Disseminated, rifampicin resistant Mycobacterium bovis (BCG) infection in an immunocompromised child. Wellcome Open Research 2020; 5: 242.
  2. Lin GL, Golubchik T, Drysdale S, O’Connor D, Jefferies K, Brown A, de Cesare M, Bonsall D, Ansari MA, Aerssens J, Bont L, Openshaw P, Martinón-Torres F, Bowden R, Pollard AJ. Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants. J Infect Dis. 2020 Jul 23:jiaa448. doi: 10.1093/infdis/jiaa448. Online ahead of print.
  3. Jefferies K, Drysdale SB, Robinson H, Clutterbuck EA, Blackwell L, McGinley J, Lin GL, Galal U, Nair H, Aerssens J, Öner D, Langedijk A, Bont L, Wildenbeest JG, Martinon-Torres F, Rodríguez-Tenreiro Sánchez C, Nadel S, Openshaw P, Thwaites R, Widjojoatmodjo M, Zhang L, Nguyen TL, Giaquinto C, Giordano G, Baraldi E, Pollard AJ; Respiratory Syncytial Virus Consortium in Europe (RESCEU) Investigators. Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae: Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU). J Infect Dis. 2020 Aug 14:jiaa239. doi: 10.1093/infdis/jiaa239. Online ahead of print.
  4. Öner D, Drysdale SB, McPherson C, Lin GL, Janet S, Broad J, Pollard AJ, Aerssens J; RESCEU Investigators. Biomarkers for Disease Severity in Children Infected With Respiratory Syncytial Virus: A Systematic Literature Review. J Infect Dis. 2020 Aug 14:jiaa208. doi: 10.1093/infdis/jiaa208. Online ahead of print.
  5. Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes J, Pollard AJ. Airway response to respiratory syncytial virus has incidental antibacterial effects. Nat Commun. 2019;10(1):2218. doi: 10.1038/s41467-019-10222-z.

Project Manager

Suzannah Wright

Suzannah is a Project Manager with over five years’ experience working in clinical trials. She primarily supports the paediatric vaccine studies, working closely with the multidisciplinary team at St George’s Vaccine Institute to set up and co-ordinate the clinical trials.

Operations Manager

Tatiana Munera Huertas

Tatiana (Taty) is the Operations Manager responsible for the strategic planning and overall direction of the group.  She is a group leader with more than 10 years’ experience coordinating and managing a large international portfolio of research studies, including observational studies and phase I-IV adult, maternal, paediatric and neonatal clinical trials funded by national and international agencies and commercial companies. She is a microbiologist by training and joined the PIDRG in 2010 after finishing her PhD in Molecular Biology at Imperial College London.

Email:tmunerah@sgul.ac.uk

Phone:+44 (0) 2087255214

Project Manager

Uzma Khan

I am a MSc graduate in Preventive Cardiology and clinical trials from Imperial College University of London with experience in clinical trials over 4 years. I have been working with the PIDRG since 2018 and am responsible for effective project management of a variety of phase 1 – 4 clinical trials, ensuring they are delivered on time, within budget and in compliance with regulatory requirement.  I have worked on studies that focused on group B meningococcal vaccines, whooping cough vaccines as well as RSV vaccines and have coordinated multi-centre studies. Recently, I have been promoted to a Project Manager and have been coordinating the COVID19 phase 2/3 vaccine trial at St Georges’ University London.

Uzma has been working with the PIDRG since 2018 and is responsible for effective project management of a variety of phase 1 – 4 clinical trials, ensuring they are delivered on time, within budget and in compliance with regulatory requirement.  Recently, she been coordinating the COVID19 phase 2/3 vaccine trial at St Georges’ University London.

Uzma has been working with the PIDRG since 2018 and is responsible for effective project management of a variety of phase 1 – 4 clinical trials, ensuring they are delivered on time, within budget and in compliance with regulatory requirement. Recently, she has been coordinating the COVID19 phase 2/3 vaccine trial at St Georges’ University London and has completed her PRINCE2 certification.

Email:uzkhan@sgul.ac.uk

Research Midwife

Vanessa Greening

Vanessa is a research midwife within the Paediatric Infectious Diseases Group within the Vaccine Institute, leading on studies that involve surveillance, interventions or treatments in pregnancy.

Prior to her role in research, Vanessa worked as a clinical midwife in multiple maternity units across the UK and abroad. She trained in Southampton graduating in 2010.

Paediatric Clinical Research Fellow

Zsofia Danos

Zsofia has been working in clinical paediatrics since 2014 and finished Paediatric training in November 2020. Zsofia started working for the paediatric infectious disease research group in September 2020. Her role as a clinical research fellow (currently mainly involved in the COVID-19 vaccine trials) includes recruitment and consenting of participants, reviewing medical history, vaccinating, conducting symptomatic reviews and covering on-call duties. Zsofia also works on the cChips CMV study and looking forward to be involved in other paediatric trials as well.

 

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

A Folyovich, I Vastagh, A Kéri, A Majoros, KL Kovács, A Ajtay, Zs Laki, B Gunda, K Erdei, L Lenti, Zs Dános, D Bereczki  Living standard is related to microregional differences in stroke characteristics in Central Europe: the Budapest Districts 8-12 Project  Int J Public Health  DOI 10.1007/s00038-015-0674-y  2015

D. Bereczki, A. Ajtay, A. Majoros, Z. Dános, L. Lenti, K. Erdei, L.K. Kovács, B. Gunda, Z. Laki, A. Kéri, I, Vastagh, A. Folyovich  Gender difference in the living standard on 3-year stroke fatality: the Budapest District 8-12 project.